
O'Higgins Region Vacations & Trips from $314
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Your O'Higgins Region Vacation
See and do more with a vacation package to O'Higgins Region. Whether you're going for the culture, festivals, history, or something else, our package deals make travel planning simple. A trip to O'Higgins Region wouldn't be complete without exploring some of its best cities, starting with Santa Cruz. A couple of the top attractions here include Lapostolle Clos Apalta Winery and Casino Colchagua. Rancagua should also be on the itineraries of all O'Higgins Region travelers. Visitors to this exciting destination enjoy Parque Safari Chile and Reserva Nacional Rio Cipreses. Expedia has hotels, flights and whatever else you need to help you curate your own tailored O'Higgins Region vacation today.
Top destinations in O'Higgins Region

Santa Cruz
The Latest O'Higgins Region Vacation Packages

45 by Director
Reviewed on Jul 3, 2025

Hotel los Españoles Plus
Reviewed on Jan 1, 2025


Hotel Director Vitacura
Reviewed on Aug 12, 2025
O'Higgins Region Hotel Deals

Vik Chile
Reviewed on Feb 22, 2025

Santa Cruz Plaza
Reviewed on Jun 6, 2025

Hotel Terrado Rancagua
Reviewed on Jul 11, 2025
Discover the most popular places to visit in O'Higgins Region

Lobos Point
Commune with nature and explore the great outdoors at Lobos Point during your travels in Pichilemu. Stroll along the seaside or discover the area's mountain views.
Lapostolle Clos Apalta Winery
You can enjoy a tasting or tour at Lapostolle Clos Apalta Winery during your travels to Santa Cruz. While in this relaxing area, you can savor the wineries and restaurants.
Monticello Grand Casino and Convention Center
Why not try your luck with a visit to Monticello Grand Casino and Convention Center during your visit to Mostazal? Make some time to visit the casinos while you're in the area.
What to do in O'Higgins Region

Santiago Full day tour to Colchahua Valley, include entraces

Private Colchagua VIK and Montes Wineries Experience
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